When David fought Goliath, he didn't try to wrestle him. Instead, he slung one of his stones at the giant's head and felled him
He knew his advantage. Yes, he was tiny. But he was a great shot with his sling and he was able to use his strengths to win what people thought was an impossible fight.
In comics there are a lot of Davids trying to wrestle giants. Independent creators who are fighting to compete with mainstream publishers when those companies have more manpower, greater resources, and larger fanbases.